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Neurology Year-in-review—Pediatric Neurology is still not clear whether anticonvulsant drug use to suppress nocturnal seizures in these children helps, hurts, or does not alter the cognitive and behavioral consequences of benign rolandic epilepsy. A prospective study of 1,267 infants from Finland examined the association between infantile colic and the subsequent development of migraine. 9 Thirteen percent of this cohort developed colic by 3 months of age; 16 % developed migraine by adolescence. Migraine developed in 23 % of those who had had infantile colic and 11 % of those who had not. Colic confered an approximately threefold higher risk for migraine without aura, but no increased risk for migraine with aura. This study highlights the arbitrariness of the line we draw between child and adult neurology and the need for healthcare providers to obtain personal and family history information across the entire lifespan when evaluating patients of any age. 1. 2. 3. 4. Yang Y, Muzny DM, Xia F, et al., Molecular findings among patients referred for clinical whole-exome sequencing, JAMA, 2014;312:1870–9. Srivastava S, Cohen JS, Vernon H, et al., Clinical whole exome sequencing in child neurology practice, Ann Neurol, 2014;76:473–83. Smith T, Klorman R, Mruzek DW, Predicting outcome of community-based early intensive behavioral intervention for children with autism, J Abnorm Child Psychol, 2015 [Epub before print]. Cascio MA, Rigid therapies, rigid minds: Italian professionals’ U S N E U ROL OGY 5. 6. 7. Finally, a multinational study led by an investigator from Uganda evaluated the effect of symptomatic interventions on quality of life and outcome in the cryptogenic childhood epileptic encephalopathy, nodding syndrome. 10 Nodding syndrome affects thousands of children in Africa and is characterized by progressive atonic, myoclonic, and tonic–clonic seizures, behavioral change, cognitive and motor decline, and malnutrition. This study demonstrated substantive improvements in quality of life and ultimate outcome with aggressive treatment including sodium valproate for seizures; vigorous nutritional intervention; mental health services for affected children and their families; and physical, occupational, and speech therapy. This study illustrates the principle that, while we must continue to support and perform research towards the eventual cure and prevention of diseases like nodding syndrome, there is much we can and must do for those children and families living with neurodevelopmental disease right now. n perspectives on autism interventions, Cult Med Psychiatr, 2015;39:235–53. Tyler KL, Rationale for the evaluation of fluoxetine in the treatment of enterovirus d68-associated acute flaccid myelitis, JAMA Neurology, 2015;39:235–53. Uliel-Sibony S, Kramer U, Benign childhood epilepsy with Centro-Temporal spikes (BCECTSs), electrical status epilepticus in sleep (ESES), and academic decline – How aggressive should we be? Epilepsy Behav, 2015;44:117–20. Vannest J, Tenney JR, Gelineau-Morel R, et al., Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes, Epilepsy Behav, 2015;45:85–91. Xiao F, An D, Chen S, et al., Clinical and electroencephalographic (EEG) features associated with refractoriness in benign childhood epilepsy with centrotemporal spikes, J Child Neurol, 2015 [Epub before print].  9. Sillanpää M, Saarinen M, Infantile colic associated with childhood migraine: A prospective cohort study, Cephalalgia, 2015 [Epub before print].  10. Idro R, Namusoke H, Abbo C, et al., Patients with nodding syndrome in Uganda improve with symptomatic treatment: a cross-sectional study, BMJ Open, 2014;4:e006476. 8. 107