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Neurology Year-in-review—Pediatric Neurology
is still not clear whether anticonvulsant drug use to suppress nocturnal
seizures in these children helps, hurts, or does not alter the cognitive and
behavioral consequences of benign rolandic epilepsy.
A prospective study of 1,267 infants from Finland examined the
association between infantile colic and the subsequent development of
migraine. 9 Thirteen percent of this cohort developed colic by 3 months
of age; 16 % developed migraine by adolescence. Migraine developed in
23 % of those who had had infantile colic and 11 % of those who had
not. Colic confered an approximately threefold higher risk for migraine
without aura, but no increased risk for migraine with aura. This study
highlights the arbitrariness of the line we draw between child and adult
neurology and the need for healthcare providers to obtain personal and
family history information across the entire lifespan when evaluating
patients of any age.
Yang Y, Muzny DM, Xia F, et al., Molecular findings among
patients referred for clinical whole-exome sequencing, JAMA,
2014;312:1870–9. Srivastava S, Cohen JS, Vernon H, et al., Clinical whole
exome sequencing in child neurology practice, Ann Neurol,
2014;76:473–83. Smith T, Klorman R, Mruzek DW, Predicting outcome of
community-based early intensive behavioral intervention
for children with autism, J Abnorm Child Psychol, 2015 [Epub
Cascio MA, Rigid therapies, rigid minds: Italian professionals’
U S N E U ROL OGY
7. Finally, a multinational study led by an investigator from Uganda evaluated
the effect of symptomatic interventions on quality of life and outcome in
the cryptogenic childhood epileptic encephalopathy, nodding syndrome. 10
Nodding syndrome affects thousands of children in Africa and is
characterized by progressive atonic, myoclonic, and tonic–clonic seizures,
behavioral change, cognitive and motor decline, and malnutrition. This
study demonstrated substantive improvements in quality of life and
ultimate outcome with aggressive treatment including sodium valproate
for seizures; vigorous nutritional intervention; mental health services
for affected children and their families; and physical, occupational, and
speech therapy. This study illustrates the principle that, while we must
continue to support and perform research towards the eventual cure and
prevention of diseases like nodding syndrome, there is much we can and
must do for those children and families living with neurodevelopmental
disease right now. n
perspectives on autism interventions, Cult Med Psychiatr,
2015;39:235–53. Tyler KL, Rationale for the evaluation of fluoxetine in the
treatment of enterovirus d68-associated acute flaccid myelitis,
JAMA Neurology, 2015;39:235–53.
Uliel-Sibony S, Kramer U, Benign childhood epilepsy with
Centro-Temporal spikes (BCECTSs), electrical status epilepticus
in sleep (ESES), and academic decline – How aggressive should
we be? Epilepsy Behav, 2015;44:117–20.
Vannest J, Tenney JR, Gelineau-Morel R, et al., Cognitive and
behavioral outcomes in benign childhood epilepsy with
centrotemporal spikes, Epilepsy Behav, 2015;45:85–91.
Xiao F, An D, Chen S, et al., Clinical and electroencephalographic
(EEG) features associated with refractoriness in benign
childhood epilepsy with centrotemporal spikes, J Child Neurol,
2015 [Epub before print].
9. Sillanpää M, Saarinen M, Infantile colic associated with
childhood migraine: A prospective cohort study, Cephalalgia,
2015 [Epub before print].
10. Idro R, Namusoke H, Abbo C, et al., Patients with nodding
syndrome in Uganda improve with symptomatic treatment: a
cross-sectional study, BMJ Open, 2014;4:e006476.