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Headache An Algorithm of Migraine Treatment Proceedings of a Symposium Presented at the XXI World Congress of Neurology in Vienna, Austria, 24 September 2013 Expert Review by: Stefan Evers 1 and Carlo Lisotto 2 1. Professor of Neurology, University of Münster and Director, Department of Neurology, Krankenhaus Lindenbrunn, Germany; 2. Neurologist, Headache Centre, Department of Neurosciences, University of Padua, Italy Abstract A satellite symposium at the XXI World Congress of Neurology 2013 presented the third edition of the International Classification of Headache Disorders and summarised the main changes, which reflect the importance of diagnosis based on phenomenology rather than aetiology. For this reason, a treatment algorithm for migraines has been created to assess the correct pathway and to reinforce the fact that triptans are the most effective treatment option. The symposium also discussed new guidelines regarding efficacy parameters in clinical trials, emphasising the importance of sustained pain free without relapse, an outcome measure that is important to patients. Crossover patient preference trials represent a true intra-individual comparison and allow the assessment of multiple endpoints defined by the patient preference, rather than the investigator. In clinical studies, frovatriptan has shown favourable tolerability and sustained effect with a lower rate of relapse compared with other triptans. These findings were confirmed in a series of patients who participated in the preference trials. Keywords Headache classification, migraine, frovatriptan, triptans Disclosure: Stefan Evers received honoraria from Menarini for consulting and as a speaker. Carlo Lisotto has occasionally served as scientific consultant for manufacturers. Acknowledgements: Editorial assistance was provided by Katrina Mountfort at Touch Medical Media. Received: 25 November 2013 Accepted: 2 December 2013 Citation: European Neurological Review, 2013;8(2):149–52 Correspondence: Stefan Evers, Department of Neurology, Krankenhaus Lindenbrunn, Lindenbrunn 1, 31863, Coppenbrügge, Germany. E: everss@uni-muenster.de Support: The publication of this article was supported by Menarini. The views and opinions expressed are those of the expert presenters and not necessarily those of Menarini. Migraine is a common disabling primary headache disorder. In the World Health Organization (WHO) Global Burden of Disease Survey 2010, it was ranked as the third most prevalent disorder and seventh-highest specific cause of disability worldwide. 1,2 In 1991, the first triptan was released in Europe for use in acute migraine, followed by the US in 1993. Evidence-based treatment guidelines state that triptans are a first-line treatment option for migraines. 3–5 However, triptans continue to be underutilised. There remains a false concern, among practitioners and patients, about possible safety issues, despite the evidence that triptans are safe and generally well tolerated. Following the publication of the third edition of the International Classification of Headache Disorders (ICHD), 6 a satellite symposium, chaired by Stefan Evers, was held at the XXI World Congress of Neurology, Vienna, 21–26 September 2013. This article summarises the proceedings of the symposium, including changes to headache classifications, new guidelines regarding efficacy parameters in clinical trials, the importance of patient preference trials and clinical cases. New Diagnostic and Severity Criteria for Migraine and Other Headaches – What is New? Headache classification enables the implementation of a standardised and evidence-based approach to carrying out and reporting of © TO U CH MED ICA L MEDIA 201 3 clinical trials. Classification also allows effective management of migraine patients, especially when the diagnosis is uncertain. In the past, headache classification was based on pathophysiology, which was of limited use. More recent classifications have been based on phenomenology rather than pathology or aetiology. The ICHD third edition (ICHD-3 beta version) has recently been published. 6 The beta (preliminary) version has been published ahead of the final version to enable field testing for inclusion in the WHO International Classification of Diseases, ICD-11, in 2016. The following is a brief summary of what is new in ICHD-3 beta. Primary and Secondary Headaches • • It is important to classify syndromes and not patients, such as avoiding the use of the term migraineur, and to recognise that a patient can have several headache types. When classifying headaches, specificity is more important than sensitivity: the aim is to have homogeneous patient groups and to have no doubt about a migraine diagnosis. Changes in Primary Headache • If patients fulfil the criteria for both chronic tension-type headache and chronic migraine, the latter should be the only diagnosis. 149