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Foreword Martin Farlow
Martin Farlow is Professor of Neurology and Vice-Chairman of Research in the Department of Neurology at the Indiana University School of
Medicine in Indianapolis. He is also Associate Co-Director of the Indiana Alzheimer’s Disease Center in Indianapolis and leads a large Alzheimer
and related dementias clinical trials site, having led and/or contributed to over 150 clinical trials over the last 25 years. Dr. Farlow is a member of
many professional associations including the AAN, ANA and AGS. He is also a founding member in both the American Society of Experimental
Neurotherapeutics and the International Society for CNS Clinical Trials and Methodology. Dr. Farlow has lectured on topics of aging, dementia, and
Alzheimer’s disease at more than 300 meetings, conferences, and hospitals/medical schools throughout the world. A prolific author, Dr. Farlow
has presented more than 470 abstracts at professional meetings and has authored or co-authored more than 460 articles published in
peer-reviewed journals. Dr. Farlow’s research focuses on clinical trials of investigational drugs for the treatment of Alzheimer’s disease and related
dementias, being the lead investigator on major studies including tacrine, donepezil, rivastigmine, CAD106 and solanezumab. Dr. Farlow also has
clinically characterized and helped determine genetic linkage for several familial dementias including the second mutation associated with
autosomal dominantly inherited Alzheimer’s disease, Gerstmann-Straussler-Scheinker disease, and multi-systems tauopathy with dementia.
W elcome to the fall edition of US Neurology. This issue features a number of topical articles that have been
chosen for their evaluation of current practices and research that directly affect neurologists and other
practitioners involved in the care of patients with neurological illness.
We begin with an editorial on the subject of Alzheimer’s disease (AD), a condition that is becoming more common in
our aging population. Drug candidates in AD have a high failure rate, and poor early detection methods make clinical
trials difficult and expensive. Cummings et al. discuss the role of default mode network assessment using functional
magnetic resonance imaging (MRI) in phase II clinical trials, a method that could provide more robust information to
justify a phase III study.
Patients with multiple sclerosis (MS) face a number of challenges in terms of physiological, psychological, cognitive,
social, and spiritual needs, and this is addressed by three articles. In an editorial, Zackowski discusses the need for
an evidence-based exercise prescription for people living with MS. Gallagher and Bethoux review the benefits of the
therapeutic arts including art therapy, dance and movement therapy, and music therapy, in promoting self-efficacy,
emotional well-being, and motor control in people with MS. In addition, Kannan and Yadav describe the role of
vascular disease risk factors such as obesity, smoking, hyperlipidemia, hypertension, type 2 diabetes and metabolic
syndrome, on outcomes in people with MS.
This issue contains two articles on epilepsy. The first, an editorial by Fisher, presents the important changes in the
International League Against Epilepsy revised operational classification of seizure types. In the second, an expert
interview, Harden discusses the challenges of sudden unexpected death in epilepsy, why new guidelines were
needed from the American Academy of Neurology and the American Epilepsy Society, and the key recommendations
of these new guidelines.
Movement disorders remain an important focus of the neurology world. Talman and Shah review the latest data on
the emerging surgical technique of MRI-guided focused ultrasound, which has demonstrated efficacy and safety in
patients with essential tremor and is now under clinical investigation for the treatment of Parkinson’s disease (PD).
Also on the subject of PD, Barrett discusses risk factors for psychosis in patients with PD, a characteristic symptom
that is associated with a more severe disease burden.
In another review, Kahkeshani and Sheikh discuss the significance of headache in the emergency room and the need
to rule out dangerous causes of this common clinical presentation. Finally, Darki and Beydoun present an interesting
case of delayed appearance of conductance block in multifocal neuropathy (MMN). MMN is a rare but treatable
condition that is frequently misdiagnosed, and this case emphasizes the importance of its early recognition.
US Neurology would like to thank all expert authors who contributed towards this edition. Special thanks to our
Editorial Board for their continuing support and guidance. We are also grateful to all organisations and media
partners for their ongoing support. We trust that you will find this edition of US Neurology useful and insightful.
TOU CH MED ICA L MEDIA