Articles
"Disease-modification" trials in Parkinson disease: target populations, endpoints and study design
However, presently, no fully satisfying efficacy "disease-modification" study design exists, and no drug has yet been approved for that indication....
A New Concept and New Criteria for Alzheimer's Disease
This two-step procedure, which relies on the Diagnostic and Statistic Manual of Mental Disorders IV Text Revision (DSM-IV-TR) and the National...
A Pathophysiological Role for Selective Alteration of the Cytokine–Chemokine Network—Inflammatory Theory in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia, and worldwide affects 20–30 million individuals over 60 years of age. In 1907 Alois...
A Review of Intra-operative Magnetic Resonance Systems
Image-guided surgery (IGS) systems have brought both the raw and processed images into the operating room (OR) and clarified the relationship between...
A Review of the First Transdermal Treatment for Alzheimer’s Disease – The Rivastigmine Patch
Currently, cholinesterase inhibitors are the mainstay in clinical practice of symptomatic treatment for Alzheimer’s disease (AD). They are believed...
A Year in Neurology
Multiple Sclerosis In multiple sclerosis (MS), 2008 has been a big year in terms of diseasemodifying therapies. Results from key clinical trials...
Acute Hypertension in Intracerebral Haemorrhage - Pathophysiology and Management
There have been many studies showing the elevation of the blood pressure after ICH.7-10 Qureshi et al.,11 in their large cross-sectional study,...
Acute Hypertension in Intracerebral Hemorrhage Pathophysiology and Management
There have been many studies showing the elevation of the blood pressure after ICH.7-10 Qureshi et al.,11 in their large cross-sectional study,...
Acute Ischemic Stroke Treatment
Paradigm Shift in Acute Stroke Care Probably the most important paradigm shift in acute stroke care was with the National Institute of Neurological...
Addressing the Psychiatric Sequelae of Catastrophic Trauma
Even though major disasters have always been with us, only relatively recently has scientific research involved large-scale systematic investigation...
Advances in Diagnostic and Therapeutic Ultrasound
The first clinical studies using microbubbles and ultrasound for treatment of ischaemic stroke have shown encouraging results.4 Further new...
Advances in Interventional Therapeutic Options for Treatment of Aneurysmal Subarachnoid Hemorrhage
Although placement of particles and other agents, including platinum coils, were subsequently attempted, it was not until the late 1980s, when...
Advances in Medical Management of Cluster Headache
The second edition of the headache classification from the International Headache Society (IHS) has defined a new primary headache grouping named the...
Advances in Neurosurgery Intra-operative Magnetic Resonance Imaging
Prior to the development of intra-operative imaging tools, surgery relied on images acquired pre-operatively. However, during the surgical...
Advances in Surgery for Pituitary Tumors
Behavior of Pituitary Tumors One of the most notable features of pituitary adenomas is their ubiquity in population studies compared with the...
Advances in the Treatment of Cluster Headache
General Diagnostic Matters Concerning Trigeminal Autonomic Cephalalgias Recently, some important diagnostic matters have arisen around TACs. These...
Advances in Treating Multiple Sclerosis
After its reintroduction to the market, natalizumab was reserved for carefully selected patients under strict surveillance and for a limited period...
Advances in Trigeminal Neuralgia
TN, or ‘tic douloureux’, is most easily recognised in medical practice as “a sudden, usually unilateral, brief stabbing recurrent...
Alzheimer's Disease Therapeutics
This delay in recognition of AD as a major neurological disease of aging does not reflect its impact.There are the personal tragedies that accompany...
Alzheimer’s Disease and Adult Neurogenesis—Are Endogenous Stem Cells Part of the Solution?
Numerous clinical trials are under way to evaluate therapeutic approaches to stop the progression of Alzheimer’s disease (AD). Despite the...
