Articles

"Disease-modification" trials in Parkinson disease: target populations, endpoints and study design

However, presently, no fully satisfying efficacy "disease-modification" study design exists, and no drug has yet been approved for that indication....

A New Concept and New Criteria for Alzheimer's Disease

This two-step procedure, which relies on the Diagnostic and Statistic Manual of Mental Disorders IV Text Revision (DSM-IV-TR) and the National...

A Pathophysiological Role for Selective Alteration of the Cytokine–Chemokine Network—Inflammatory Theory in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common form of dementia, and worldwide affects 20–30 million individuals over 60 years of age. In 1907 Alois...

A Review of Intra-operative Magnetic Resonance Systems

Image-guided surgery (IGS) systems have brought both the raw and processed images into the operating room (OR) and clarified the relationship between...

A Review of the First Transdermal Treatment for Alzheimer’s Disease – The Rivastigmine Patch

Currently, cholinesterase inhibitors are the mainstay in clinical practice of symptomatic treatment for Alzheimer’s disease (AD). They are believed...

A Year in Neurology

Multiple Sclerosis In multiple sclerosis (MS), 2008 has been a big year in terms of diseasemodifying therapies. Results from key clinical trials...

Acute Hypertension in Intracerebral Haemorrhage - Pathophysiology and Management

There have been many studies showing the elevation of the blood pressure after ICH.7-10 Qureshi et al.,11 in their large cross-sectional study,...

Acute Hypertension in Intracerebral Hemorrhage Pathophysiology and Management

There have been many studies showing the elevation of the blood pressure after ICH.7-10 Qureshi et al.,11 in their large cross-sectional study,...

Acute Ischemic Stroke Treatment

Paradigm Shift in Acute Stroke Care Probably the most important paradigm shift in acute stroke care was with the National Institute of Neurological...

Addressing the Psychiatric Sequelae of Catastrophic Trauma

Even though major disasters have always been with us, only relatively recently has scientific research involved large-scale systematic investigation...

Advanced Neuroimaging for Modern Epilepsy Surgery

When neurosurgeons first attempted to treat epilepsy by means of surgery in the late 1800s, they were operating on ‘invisible’ lesions. Without...

Advances in Diagnostic and Therapeutic Ultrasound

The first clinical studies using microbubbles and ultrasound for treatment of ischaemic stroke have shown encouraging results.4 Further new...

Advances in Interventional Therapeutic Options for Treatment of Aneurysmal Subarachnoid Hemorrhage

Although placement of particles and other agents, including platinum coils, were subsequently attempted, it was not until the late 1980s, when...

Advances in Medical Management of Cluster Headache

The second edition of the headache classification from the International Headache Society (IHS) has defined a new primary headache grouping named...

Advances in Medical Management of Cluster Headache

The second edition of the headache classification from the International Headache Society (IHS) has defined a new primary headache grouping named the...

Advances in Neurosurgery Intra-operative Magnetic Resonance Imaging

Prior to the development of intra-operative imaging tools, surgery relied on images acquired pre-operatively. However, during the surgical...

Advances in Our Understanding of Dystonia – Pathophysiology and Treatment Options

Dystonia is characterised by involuntary muscle contractions causing twisting movements and abnormal postures.1 It is clinically and aetiologically...

Advances in Our Understanding of Dystonia— Pathophysiology and Treatment Options

Dystonia is characterized by involuntary muscle contractions causing twisting movements and abnormal postures.1 It is clinically and etiologically...

Advances in Our Understanding of the Pathophysiology of Alzheimer's Disease

Alzheimer’s disease (AD) is a neurodegenerative age-related progressive disease and the most common cause of dementia in the elderly.1 Current...

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