Articles
What causes breakthrough seizures?There are a number of potential causes of the unexpected occurrence of a breakthrough seizure. One important factor...
First Seizure and New Onset EpilepsyWhen a patient has suffered the first epileptic seizure, a decision whether to treat or not is based on the risk...
However, at this time, many questions are still unanswered and many options are still debated. What is the appropriate structure to stimulate or to...
Epilepsy and Depression – A Bi-directional RelationshipAssessing the prevalence of depression from selected clinical samples of patients with...
Therapy of epilepsy is based on a correct diagnosis of the epilepsy syndrome, appropriate choice of medication(s), early identification of medically...
Women present a special complexity in terms of tolerability because there are several issues to consider and the weighting of these issues may change...
The concept of compliance is important because negative outcomes such as increased seizure frequency, increased hospital admissions, loss of driving...
His research interests include antiepileptic drug neuropharmacology, the management of epilepsy and factors affecting outcome, which has resulted in...
The ideal medical management of epilepsy is based on tailoring each patient’s regimen to his or her seizure type, comorbidities, lifestyle, and...
Although every seizure type can theoretically persist and evolve into SE, a simple 2D SE classification system can be constructed, either generalized...
Epilepsy is a common neurological disorder, affecting 1–2% of the population worldwide, and is characterised by recurrent spontaneous seizures....
Depending on the pattern of neuronal involvement, the symptomatology (or semiology) of a seizure may consist of a wide range of sudden and transitory...
VNS has become an invaluable tool in the treatment of refractory epilepsy. It is cost-effective3-6 and has been shown to reduce the number of...
Proposed Mechanisms of Vagus Nerve StimulationThe mechanism by which VNS exerts its effect has not been fully elucidated.However, several studies...
Only in a few situations is the best choice not to start treatment. For instance, in benign rolandic epilepsy with only nightly, partial seizures...
Following the first encouraging human trials in 1988, 1,2 several controlled studies have demonstrated the antiepileptic efficacy of adjunctive vagus...
How has the KD changed from an unproven, ‘alternative’ epilepsy treatment to an established, non-pharmacological medical therapy over the...
The symptomatic focal epilepsy is the most frequently diagnosed type. Main causes are strokes 6,7 followed by brain tumours4 and degenerative...
Mechanism of Action of Topiramate Although the exact mechanism of action of TPM remains unknown, multiple mechanisms have been hypothesised based on...
Several new AEDs—felbamate, gabapentin, lamotrigine, levetiracetam (LEV), oxcarbazepine, tiagabine, topiramate, vigabatrin, zonisamide, and...
