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Friday, 21 November, 2008



Multiple Sclerosis News


Keeping you up to date with the latest clinical trial information

Multiple Sclerosis

Antibodies against Human Cytomegalovirus in the Pathogenesis of Systemic Sclerosis: A Gene Array Approach
Systemic sclerosis is an autoimmune disease characterized by immunological abnormalities, vascular damage, and fibroblast proliferation. We have previously shown that a molecular mimicry mechanism links antibodies against the human-cytomegalovirus-derived protein UL94 to the pathogenesis of systemic sclerosis.

Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon?
Despite the significant progress in increasing our understanding of the immune mechanisms of multiple sclerosis (MS), in improving clinical classification and brain imaging, and in developing new treatments, the factors that determine the course of the disease are mostly unknown.

Test Your Knowledge: Ten Questions about Multiple Sclerosis
Concerns about adverse events, including deaths, in recent large clinical trials, both publicly and privately sponsored, prompted Elias A. Zerhouni, Director, National Institutes of Health (NIH) to convene a meeting at the NIH


Zenapax (Daclizumab) to Treat Relapsing Remitting Multiple Sclerosis



This study will examine the safety of Zenapax (daclizumab) in patients with multiple sclerosis (MS). MS is thought to be caused by an over-reactive immune response. T-lymphocytes (cells of the immune system), are thought to damage myelin, a substance that covers the nerve and parts of the spinal cord and is damaged in patients with MS. Interleukin-2 is a natural substance in the body that is necessary for the growth of T-lymphocytes. Zenapax is a genetically engineered antibody that blocks the activity of interleukin-2 and thus interferes with the growth of lymphocytes. Therefore, Zenapax may prevent some of the damage to myelin that occurs in multiple sclerosis.
Selected Reading

Auditory Function in Patients With and Without Multiple Sclerosis

We propose to evaluate auditory function and neuropsychologic function in 150 Multiple Sclerosis (MS) patients and in 150 patients who do not have MS. Experimental subjects will be recruited by selecting patients with a verified diagnosis of MS from the registry of patients established by the Oregon Health Sciences University, Multiple Sclerosis Research Center. Control subjects will be matched with respect to age, to gender and to audiometric configuration.

Selected Reading
Newly FDA-approved drugs

Tysabri (natalizumab) Injection
Approved: November 23, 2004 Company: Biogen Idec / Elan Corporation, plc
Treatment for: Multiple Sclerosis
Tysabri (formerly referred to as Antegren) is a recombinant humanized monoclonal antibody indicated for the treatment of patients with relapsing forms of multiple sclerosis (MS)
Guidelines Watch
A round up of the latest Clinical Guidelines from the National Guideline Clearinghouse (NGC)

Multiple Sclerosis

Multiple sclerosis. National clinical guideline for diagnosis and management in primary and secondary care
National Collaborating Centre for Chronic Conditions - National Government Agency [Non-U.S.]. 2004. 197 pages. NGC:003547

The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
American Academy of Neurology - Medical Specialty Society. 2003 Nov 25. 7 pages . NGC:003643



Upcoming Events
8th World Drug Discovery & Development Summit 2008
02 -  03 Dec 2008
Prague Congress Centre, Czech Republic
Clinical trial performance metrics
07 Jan -  01 Feb 2007
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