Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience

SOD1-ALS from Gene Discovery to Targeted Therapeutics: A Comprehensive Review

Joshua Newman, Phillipe Corcia, Angela Genge

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

touchREVIEWS in Neurology. 2025;21(1):Online ahead of journal publication

Headache Disorders

EAN 2016 Peter Goadsby Interview

Published Online: Jun 24th 2016

Peter Goadsby discusses the rationale for using CGRP antibodies in the treatment of migraine and the study findings so far.

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Headache disorders at EAN24: Developments and the future

Peter J Goadsby

Data from the REFORM trial (NCT04674020) provide valuable insights into cortical inflammation in adults with migraines, using a novel quantitative, multimodal MRI technique to compare these patients with age- and gender-matched healthy controls, enhancing our understanding of migraine biology and other headache disorders. The discussion also covers cluster headaches, focusing on a study that examines premonitory symptoms in affected individuals and highlights key phenotypic characteristics. Additionally, we explore findings from the European Migraine & Headache Alliance on the stigma surrounding migraines, which yield insightful and actionable results. Looking ahead, the focus shifts to the latest data on new medications for preventing and treating migraine attacks, discussing future prospects and identifying areas in headache disorder management that still need further attention.

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SOD1-ALS from Gene Discovery to Targeted Therapeutics: A Comprehensive Review

Learning Activities

Journals

Specialities

SOD1-ALS from Gene Discovery to Targeted Therapeutics: A Comprehensive Review

EAN 2016 Peter Goadsby Interview

This Content is for
Members Only

Headache disorders at EAN24: Developments and the future

Peter Goadsby, EAN 2023: Highlights in migraine

Peter Goadsby, EAN 2023: Highlights in headache disorders

Highlights from EAN 2023!

Stewart Tepper, AAN 2023: Atogepant for the preventive treatment of chronic migraine: results from the PROGRESS phase 3 trial

Atogepant for preventive treatment of chronic migraine, PROGRESS phase 3 trial: Richard Lipton, AAN 2023

Stewart Tepper, AAN 2023: Results from the PRODROME trial of ubrogepant for the acute treatment of migraine

Stewart Tepper, AAN 2023: Significant reduction in migraine days with REN for migraine prevention: A double-blind randomized sham-controlled clinical trial

Stewart Tepper, AAN 2023: Phase 3 ASCEND interim analysis - STS101 for the treatment of acute migraine

Stewart Tepper, AAN 2023: Combination of rizatriptan and AXS-07 - results from the MOMENTUM and INTERCEPT studies

Robert Music, The Migraine Trust: Improving migraine care - ensuring patient-focussed diagnosis and treatment in the UK

Raquel Gil-Gouveia, EAN 2022: Highlights in headache and migraine - Treatment advances, strategies for prevention, Anti-CGRP use in migraine, COVID-19

Stewart Tepper, AAN 2022: Limitations of current treatments for acute migraine

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