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Friday, 21 November, 2008



Dementias News


Keeping you up to date with the latest clinical trial information

Alzheimer's Disease

Interleukin-1 mediates Alzheimer and Lewy body pathologies
Parkinson's disease (PD), once thought of as a purely motor disorder, is linked to Alzheimer's disease (AD) in several ways.


Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
Alzheimer disease (AD), the most common cause of dementia in the elderly, is clinically characterized by progressive cognitive impairment associated with severe neuropsychiatric disturbances.

Test Your Knowledge: Ten Questions about Dementia
This quiz is related to the Best Practice article in the January issue of PLoS Medicine (DOI: 10.1371/journal.pmed.0020007).


Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)

The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) prevention trial is an important addition to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). As a prevention trial, PREADVISE is trying to find out if taking selenium and/or Vitamin E supplements can help to prevent memory loss and dementia such as Alzheimer's disease.

Selected Reading

Huperzine A in Alzheimer's Disease

The present study will evaluate the safety and efficacy of the Chinese herb huperzine A in the treatment of Alzheimer's disease (AD) in a randomized controlled trial of its effect on cognitive function.

Selected Reading

Depression in Alzheimer's Disease

The purpose of this study is to learn whether treating individuals with Alzheimer's disease and depression with the anti-depressant medication sertraline (Zoloft) is helpful to people with Alzheimer's disease and to their families and caregivers.

Selected Reading
Newly FDA-approved drugs

Aricept ODT (donepezil HCl) Orally Disintegrating Tablets
Approved: October 18, 2004Company: Eisai Inc.
Treatment for: Alzheimer’s Disease
Aricept ODT is a new disintegrating tablet dosage form designed to make administration easier for patients with Alzheimer’s disease. Studies have shown these patients may develop difficulty with swallowing. Aricept ODT will be available in the U.S. in the second quarter of 2005
Guidelines Watch
A round up of the latest Clinical Guidelines from the National Guideline Clearinghouse (NGC)

Dementias

Management of patients with dementia. A national clinical guideline
Scottish Intercollegiate Guidelines Network - National Government Agency [Non-U.S.]. 1998 Feb (revised 2006 Feb). 53 pages. NGC:004855

Dementia
American Medical Directors Association - Professional Association. 1998 (revised 2005). 28 pages. NGC:004446



Upcoming Events
8th World Drug Discovery & Development Summit 2008
02 -  03 Dec 2008
Prague Congress Centre, Czech Republic
Clinical trial performance metrics
07 Jan -  01 Feb 2007
To Be Confirmed, UK



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