Effective Rehabilitation Methods in Patients with Multiple Sclerosis

Effective Rehabilitation Methods in Patients with Multiple Sclerosis

US Neurology, 2010;5(2):67-71

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Abstract
The role of rehabilitation in managing symptoms of multiple sclerosis (MS) and promoting functional recovery has grown exponentially over the past 12 years. Evidence now supports strength and aerobic training for individuals with mild or moderate disease. An emerging body of evidence suggests that exercise may play a role in the production of brain-derived neurotrophic factor in individuals with MS, and the combination of pharmacological management and rehabilitation may produce better outcomes than one therapeutic intervention alone. Rehabilitation and exercise should be a major focus in the comprehensive management of MS.

Keywords
Rehabilitation, multiple sclerosis, aerobic exercise, strength training, treadmill training, brain-derived neurotrophic factor, symptom management

Disclosure: Susan E Bennett, PT, DPT, EdD, NCS, MSCS, has received speaker honoraria from Medtronic, Biogen Idec, Teva Neuroscience, EMD Serono, and Pfizer, and research funding through the Consortium of MS Centers.
Received: December 3, 2009 Accepted: January 27, 2010
Correspondence: Susan E Bennett, PT, DPT, EdD, NCS, MSCS, Department of Rehabilitation Science and Department of Neurology, University at Buffalo, 5th Floor Kimball Tower, 3435 Main Street, Buffalo, NY 14214. E: sbennett@buffalo.edu

Multiple sclerosis (MS), which affects an estimated 400,000 people in the US, is a demyelinating disease with a variable degree of injury to axons in the brain, spinal cord, and optic nerve.1 A variety of symptoms associated with MS—such as weakness, spasticity, balance problems, and ataxia—affect functional mobility and activities of daily living. Studies have also suggested that physical inactivity over a three- to fiveyear period can produce a worsening of symptoms, independent of depression, Expanded Disability Status Scale (EDSS) score, and disease course.2 Symptom management in MS has emphasized medical management, but in recent years rehabilitation has been added as an adjunctive treatment.

Research examining rehabilitation in MS has progressed rapidly within the past 10 years, with an emerging body of evidence to suggest that exercise programs have a beneficial effect on both disease symptoms and the general fitness of people with MS who are ambulatory.3 Early research reported by Gehlsen et al.,4 Chen et al.,5 Brar et al.,6 and Petajan et al.7 examined the benefits of aquatic exercise, stretching exercise, and the use of baclofen for spasticity, muscle force production in the lower extremities, and physical and psychological changes, respectively.

In the past 15 years research has focused more on the type of exercise that may have an effect on MS symptoms, as well as the role of neurological rehabilitation in functional recovery. For many patients, medications to manage the disease and symptoms, as well as aggressive rehabilitation, have led to advances in functional recovery.

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Keywords:
Rehabilitation, multiple sclerosis, aerobic exercise, strength training, treadmill training, brain-derived neurotrophic factor, symptom management, multiple sclerosis causes, multiple sclerosis symptoms, multiple sclerosis prognosis, brain-derived neurotrophic factor depression, cortical neurons,

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