Deep Brain Stimulation
Deep Brain Stimulation
Deep brain stimulation (DBS) has opened new avenues in the treatment of degenerative diseases, such as Parkinson’s disease, essential tremor and dystonia, and new trials in obsessive compulsive disorder (OCD) and depression are being conducted with promising preliminary results. Epilepsy could also benefit from this new technique and controlled, double-blind clinical trials are being conducted worldwide with the purpose of coming up with robust positive data allowing the treatment of patients suffering from intractable epilepsy with DBS.
However, at this time, many questions are still unanswered and many options are still debated. What is the appropriate structure to stimulate or to inhibit? What is the most appropriate mode of stimulation and with what parameters? Which patients could benefit from DBS? This review will give an update of clinical data available in this field and will try to shed light on these questions.
Which Targets?
Two strategies are challenged: the first one, and the oldest, aims to modulate the cortical activity by stimulating or inhibiting nuclei that are involved in the remote anti-epileptogenic zone. The latter mainly includes the thalamus (centromedian (CM) and anterior nucleus (AN)), the basal ganglia (subthalamic nucleus (STN) and substancia nigra (SNr) and the cerebellum. Vagus nerve stimulation (VNS) belongs to this group. The second strategy aims to act directly on the epileptogenic zone (EZ) at the surface of the cortex or in the hippocampus. The CM of the thalamus has been advocated as a potential therapeutic target mainly in generalised tonic-clonic seizure and atypical absences1-4 with relatively less effect in ‘partial complex’ seizure.5 However, authors have recently focused on the AN to treat patients with complex partial seizure. The first preliminary results are promising6,7 with four good responders out of five patients and with a best efficacy on secondary generalised tonic-clonic seizure and complex partial seizure with falls. Longterm results seem to confirm the preliminary data8 with a mean reduction of seizure of more than 50% in all five patients, an effect that can occur several years after the surgery and that is more pronounced after changing anti-epileptic drugs (AEDs), raising the question of the mechanism of actions and the possibility that AN DBS may render the patients more sensitive to AEDs. Based on these encouraging results, a double-blind, large multicentre control study is being conducted in North America and will give soon new insights into this field. The role of basal ganglia (STN and SNr) in the control of epilepsy has been extensively studied in animals.9,10 The author’s group applied this concept for the first time in 200211 in a young patient suffering from motor epilepsy related to a dysplasia located in the motor cortex. Four other patients have been implanted, with three good responders out of five patients (more than 50% of seizure reduction).11 Very recently, the author initiated a multicentre, crossover, double-blind study (STIMEP) to apply STN-SNr DBS on patients suffering from atypical absence (see below), related or not to ring chromosome 20 and with Dopa positron emission tomography (PET) hypometabolism as a common feature.12 Others groups have confirmed that STN DBS could be a potential target for the treatment of severe epilepsy,13-15 but so far, no large, controlled studies have confirmed the potential therapeutic effect of such treatment. Other nuclei that belong to basal ganglia have been used in the past, but to the author’s knowledge are not used any more.16 The cerebellum has been regularly cited as a potential anti-epileptogenic centre since the 1970s,17-21, but its anti-epileptic effect has been debated.22
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